Use of experimental therapies should be ethically justified, on account of by definition they enhance the query of standard of care Physicians have autonomy to provide empirical care (corresponding to off-label care) consistent with their experience and scientific judgment, nonetheless the autonomy has limits that preclude quackery Thus it might be essential to design a scientific trial across the new therapy and to use the treatment solely per a proper protocol Generally shorthand phrases akin to “handled on protocol” imply not simply “handled in keeping with a plan” but particularly “dealt with with investigational remedy”.
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